Imaging peripheral nerves

The human peripheral nervous system (PNS) is frequently affected by disorders. Clinical agents which enable visualization of the PNS would be extremely useful for many medical applications, including nerve-sparing surgical procedures, and diagnosis of PNS disorders such as chemotherapy-induced peripheral neuropathy or COVID-related anosmia. We are developing several PNS-targeted imaging agents for this purpose, based on the Naᵥ1.7-selective peptide, Hsp1a.

Project publications:

  1. Gonzales, et al. Fluorescence imaging of peripheral nerves by a Naᵥ1.7-targeted
    inhibitor cystine knot peptide.     Bioconjugate Chem. 2019 Nov; 30(11):2879-2888.

  2. Gonzales, et al. Fluorescence labeling of a Naᵥ1.7-targeted
    peptide for near-infrared nerve visualization.     EJNMMI Res. 2020 May; 10(1):49.

  3. Gonzales, et al. Bimodal imaging of mouse peripheral nerves with chlorin tracers. Mol Pharm. Mar 1;18(3):940-951.

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PSMA tracers for cancer therapy